In Mendelian randomization, liability to critical COVID‐19 was associated with increased risk of ischemic stroke (odds ratio per logOR increase in genetically predicted critical COVID‐19 liability 1.03, 95% CI 1.00–1.06, P‐value=0.03). There was evidence of genetic correlation between critical COVID‐19 and ischemic stroke (r g=0.29, false discovery rate =0.012), body mass index (r g=0.21, FDR=0.00002), and C‐reactive protein (r g=0.20, FDR=0.00035), but no other trait investigated. Mendelian randomization analysis was performed to investigate whether liability to critical COVID‐19 was associated with increased risk of any cardiovascular outcome for which genetic correlation was identified. Cross‐trait linkage disequilibrium score regression was used to estimate genetic correlations of critical COVID‐19 with ischemic stroke, other related cardiovascular outcomes, and risk factors common to both COVID‐19 and cardiovascular disease (body mass index, smoking and chronic inflammation, estimated using C‐reactive protein).
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